Maternal obesity and metabolic disorders associate with congenital heart defects in the offspring: A systematic review.

ABSTRACT:

Background

Congenital heart defects (CHDs) are the most common congenital malformations. The aetiology of CHDs is complex. Large cohort studies and systematic reviews and meta-analyses based on these have reported an association between higher risk of CHDs in the offspring and individual maternal metabolic disorders such as obesity, diabetes, hypertension, and preeclampsia, all conditions that can be related to insulin resistance or hyperglycaemia. However, the clinical reality is that these conditions often occur simultaneously. The aim of this review is, in consequence, both to evaluate the existing evidence on the association between maternal metabolic disorders, defined as obesity, diabetes, hypertension, preeclampsia, dyslipidaemia and CHDs in the offspring, as well as the sig

SUBMITTER: Hedermann G 

PROVIDER: S-EPMC8158948 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature