Global antibiotic dosing strategies in hospitalised children: Characterising variation and implications for harmonisation of international guidelines.

ABSTRACT:

Background

Paediatric global antibiotic guidelines are inconsistent, most likely due to the limited pharmacokinetic and efficacy data in this population. We investigated factors underlying variation in antibiotic dosing using data from five global point prevalence surveys.

Methods & findings

Data from 3,367 doses of the 16 most frequent intravenous antibiotics administered to children 1 month-12 years across 23 countries were analysed. For each antibiotic, we identified standard doses given as either weight-based doses (in mg/kg/day) or fixed daily doses (in mg/day), and investigated the pattern of dosing using each strategy. Factors underlying observed variation in weight-based doses were investigated using linear mixed effects models. Weight-based dosing (in mg/kg/day) clu

SUBMITTER: Clements MN 

PROVIDER: S-EPMC8159011 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature