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Metal-free electrochemical fluorodecarboxylation of aryloxyacetic acids to fluoromethyl aryl ethers.

ABSTRACT: Electrochemical decarboxylation of aryloxyacetic acids followed by fluorination provides easy access to fluoromethyl aryl ethers. This electrochemical fluorodecarboxylation offers a sustainable approach with electric current as traceless oxidant. Using Et₃N·5HF as fluoride source and as supporting electrolyte, this simple electrosynthesis affords various fluoromethoxyarenes in yields up to 85%.

SUBMITTER: Berger M

PROVIDER: S-EPMC8159297 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Metal-free electrochemical fluorodecarboxylation of aryloxyacetic acids to fluoromethyl aryl ethers.

Berger Michael M Herszman John D JD Kurimoto Yuji Y de Kruijff Goswinus H M GHM Schüll Aaron A Ruf Sven S Waldvogel Siegfried R SR

Chemical science 20200601 23

Electrochemical decarboxylation of aryloxyacetic acids followed by fluorination provides easy access to fluoromethyl aryl ethers. This electrochemical fluorodecarboxylation offers a sustainable approach with electric current as traceless oxidant. Using Et<sub>3</sub>N·5HF as fluoride source and as supporting electrolyte, this simple electrosynthesis affords various fluoromethoxyarenes in yields up to 85%. ...[more]

PMID: 34094098

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