Investigation of cellular uptake mechanism of functionalised gold nanoparticles into breast cancer using SERS.

ABSTRACT: Gold nanoparticles (AuNPs) are widely used in various applications such as cancer imaging and drug delivery. The functionalisation of AuNPs has been shown to affect their cellular internalisation, accumulation and targeting efficiency. The mechanism of cellular uptake of functionalised AuNPs by different cancer cells is not well understood. Therefore, a detailed understanding of the molecular processes is necessary to improve AuNPs for their selective uptake and fate in specific cellular systems. This knowledge can greatly help in designing nanotags with higher cellular uptake for more selective and specific targeting capabilities with less off-target effects. Here, we demonstrate for the first time a straightforward and non-destructive 3D surface enhanced Raman spectroscopy (SERS) imaging

SUBMITTER: Kapara A 

PROVIDER: S-EPMC8159335 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature