Interplay between structural parameters and reactivity of Zr₆-based MOFs as artificial proteases.

ABSTRACT: Structural parameters influencing the reactivity of metal-organic frameworks (MOF) are challenging to establish. However, understanding their effect is crucial to further develop their catalytic potential. Here, we uncovered a correlation between reaction kinetics and the morphological structure of MOF-nanozymes using the hydrolysis of a dipeptide under physiological pH as model reaction. Comparison of the activation parameters in the presence of NU-1000 with those observed with MOF-808 revealed the reaction outcome is largely governed by the Zr₆ cluster. Additionally, its structural environment completely changes the energy profile of the hydrolysis step, resulting in a higher energy barrier ΔG ^‡ for NU-1000 due to a much larger ΔS ^‡ term. Th

SUBMITTER: Loosen A 

PROVIDER: S-EPMC8159359 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature