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Enantio- and diastereoselective diarylmethylation of 1,3-dicarbonyl compounds.

ABSTRACT: A Cu-catalyzed enantio- and diastereoselective diarylmethylation of 1,3-dicarbonyl compounds is described. It is a successful example of constructing all-carbon quaternary stereocenters from 3 °C-H nucleophiles, a challenging topic in synthetic chemistry. In the present work, two contiguous stereocenters are constructed with high levels of stereoselectivity and atom economy. The broad scope of 1,3-dicarbonyl nucleophiles and the tolerance of a wide range of functional groups make this protocol of great importance in the synthesis of chiral diarylmethane compounds.

SUBMITTER: Li X

PROVIDER: S-EPMC8159382 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Enantio- and diastereoselective diarylmethylation of 1,3-dicarbonyl compounds.

Li Xin X He Songtao S Song Qiuling Q

Chemical science 20200525 23

A Cu-catalyzed enantio- and diastereoselective diarylmethylation of 1,3-dicarbonyl compounds is described. It is a successful example of constructing all-carbon quaternary stereocenters from 3 °C-H nucleophiles, a challenging topic in synthetic chemistry. In the present work, two contiguous stereocenters are constructed with high levels of stereoselectivity and atom economy. The broad scope of 1,3-dicarbonyl nucleophiles and the tolerance of a wide range of functional groups make this protocol o ...[more]

PMID: 34094087

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