Supramolecular catalysis by recognition-encoded oligomers: discovery of a synthetic imine polymerase.

ABSTRACT: All key chemical transformations in biology are catalysed by linear oligomers. Catalytic properties could be programmed into synthetic oligomers in the same way as they are programmed into proteins, and an example of the discovery of emergent catalytic properties in a synthetic oligomer is reported. Dynamic combinatorial chemistry experiments designed to study the templating of a recognition-encoded oligomer by the complementary sequence have uncovered an unexpected imine polymerase activity. Libraries of equilibrating imines were formed by coupling diamine linkers with monomer building blocks composed of dialdehydes functionalised with either a trifluoromethyl phenol (D) or phosphine oxide (A) H-bond recognition unit. However, addition of the AAA trimer to a mixture o

SUBMITTER: Gabrielli L 

PROVIDER: S-EPMC8159439 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature