Serotonin transporter availability in adults with autism-a positron emission tomography study.

ABSTRACT: Impairments in social interaction and communication, in combination with restricted, repetitive behaviors and interests, define the neurodevelopmental diagnosis of autism spectrum disorder (ASD). The biological underpinnings of ASD are not well known, but the hypothesis of serotonin (5-HT) involvement in the neurodevelopment of ASD is one of the longest standing. Reuptake through the 5-HT transporter (5-HTT) is the main pathway decreasing extracellular 5-HT in the brain and a marker for the 5-HT system, but in vivo investigations of the 5-HTT and the 5-HT system in ASD are scarce and so far inconclusive. To quantify possible alterations in the 5-HT system in ASD, we used positron emission tomography and the radioligand [¹¹C]MADAM to measure 5-HTT availability in the brain of 15

SUBMITTER: Andersson M 

PROVIDER: S-EPMC8159737 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature