Polygenic risk for obesity and its interaction with lifestyle and sociodemographic factors in European children and adolescents.

ABSTRACT:

Background

Childhood obesity is a complex multifaceted condition, which is influenced by genetics, environmental factors, and their interaction. However, these interactions have mainly been studied in twin studies and evidence from population-based cohorts is limited. Here, we analyze the interaction of an obesity-related genome-wide polygenic risk score (PRS) with sociodemographic and lifestyle factors for BMI and waist circumference (WC) in European children and adolescents.

Methods

The analyses are based on 8609 repeated observations from 3098 participants aged 2-16 years from the IDEFICS/I.Family cohort. A genome-wide polygenic risk score (PRS) was calculated using summary statistics from independent genome-wide association studies of BMI. Associations were estimated usi

SUBMITTER: Huls A 

PROVIDER: S-EPMC8159747 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature