Torque Teno Virus plasma level as novel biomarker of retained immunocompetence in HIV-infected patients.

ABSTRACT:

Purpose

To predict the course of immune recovery (IR) in HIV-1-infected patients after initiation of combined antiretroviral therapy (cART) by determination of the plasma concentration of Torque Teno Virus (TTV). TTV has been identified as marker for risk assessment in immunosuppressed patients after transplantation procedures. Here, TTV was analyzed in HIV-1-infected therapy-naïve patients to evaluate its use as predictor of the course of IR for guidance of individualized treatment.

Methods

TTV DNA was quantified in plasma samples of 301 therapy-naïve HIV-1-infected patients and correlated to CD4⁺ cell count, HIV viral load, presence of the herpes viruses CMV, EBV and HHV-8, age and sex. Patients were classified according to their initial CD4⁺ cell cou

SUBMITTER: Schmidt L 

PROVIDER: S-EPMC8159784 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature