Purinergic Receptors Crosstalk with CCR5 to Amplify Ca²⁺ Signaling.

ABSTRACT: Many G protein-coupled receptors (GPCRs) signal through more than one subtype of heterotrimeric G proteins. For example, the C-C chemokine receptor type 5 (CCR5), which serves as a co-receptor to facilitate cellular entry of human immunodeficiency virus 1 (HIV-1), normally signals through the heterotrimeric G protein, Gi. However, CCR5 also exhibits G protein signaling bias and certain chemokine analogs can cause a switch to Gq pathways to induce Ca²⁺ signaling. We want to understand how much of the Ca²⁺ signaling from Gi-coupled receptors is due to G protein promiscuity and how much is due to transactivation and crosstalk with other receptors. We propose a possible mechanism underlying the apparent switching between different G protein signaling pathways. We show tha

SUBMITTER: Horioka M 

PROVIDER: S-EPMC8159800 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature