Association between different obesity phenotypes and hypothyroidism: a study based on a longitudinal health management cohort.

ABSTRACT:

Purpose

Obese individuals have an increased risk of hypothyroidism. This study investigated the sex-specific association between obesity phenotypes and the development of hypothyroidism.

Methods

The study population was derived from a health management cohort in Shandong Provincial Hospital from 2012 to 2016. In total, 9011 baseline euthyroid adults were included and classified into four groups according to obesity phenotype: metabolically healthy nonobese (MHNO), metabolically healthy obese (MHO), metabolically unhealthy nonobese (MUNO), and metabolically unhealthy obese (MUO). The median follow-up time was 1.92 (1.00-2.17) years. Incidence density was evaluated and a generalized estimation equation method was used to investigate the associations between obesity phenotypes

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8159820 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature