Elevated serum progesterone during in vitro fertilization treatment and the risk of ischemic placental disease.

ABSTRACT:

Background

Elevated progesterone on the day of human chorionic gonadotropin (hCG) administration is associated with decreased live birth rates in IVF cycles. The association with adverse pregnancy outcomes is unknown.

Objectives

Assess the association between serum progesterone on the day of hCG administration and the risk of ischemic placental disease [IPD; preeclampsia, placental abruption, and/or small for gestational age (SGA)].

Methods

We conducted a retrospective cohort study of autologous fresh IVF cycles resulting in delivery between 2005 and 2018. All IVF procedures were conducted at a large, university-affiliated infertility center. Patients were divided into tertiles based on their serum progesterone level on the day of hCG administration; the lowest tertil

SUBMITTER: Modest AM 

PROVIDER: S-EPMC8159861 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature