Assessment of quantitative [¹⁸F]Sodium fluoride PET measures of knee subchondral bone perfusion and mineralization in osteoarthritic and healthy subjects.

ABSTRACT:

Objective

Molecular information derived from dynamic [¹⁸F]sodium fluoride ([¹⁸F]NaF) PET imaging holds promise as a quantitative marker of bone metabolism. The objective of this work was to evaluate physiological mechanisms of [¹⁸F]NaF uptake in subchondral bone of individuals with and without knee osteoarthritis (OA).

Methods

Eleven healthy volunteers and twenty OA subjects were included. Both knees of all subjects were scanned simultaneously using a 3T hybrid PET/MRI system. MRI MOAKS assessment was performed to score the presence and size of osteophytes, bone marrow lesions, and cartilage lesions. Subchondral bone kinetic parameters of bone perfusion (K₁), tracer extraction fraction, and total tracer uptake into bone (K_i

SUBMITTER: Watkins L 

PROVIDER: S-EPMC8159876 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature