Gene expression alterations in salivary gland epithelia of Sjogren's syndrome patients are associated with clinical and histopathological manifestations.

ABSTRACT: Sjögren's syndrome (SS) is a complex autoimmune disease associated with lymphocytic infiltration and secretory dysfunction of salivary and lacrimal glands. Although the etiology of SS remains unclear, evidence suggests that epithelial damage of the glands elicits immune and fibrotic responses in SS. To define molecular changes underlying epithelial tissue damage in SS, we laser capture microdissected (LCM) labial salivary gland epithelia from 8 SS and 8 non-SS controls for analysis by RNA sequencing (RNAseq). Computational interrogation of gene expression signatures revealed that, in addition to a division of SS and non-SS samples, there was a potential intermediate state overlapping clustering of SS and non-SS samples. Differential expression analysis uncovered signaling events likely ass

SUBMITTER: Dela Cruz A 

PROVIDER: S-EPMC8159963 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature