Designing a multi-epitope vaccine against Mycobacteroides abscessus by pangenome-reverse vaccinology.

ABSTRACT: Mycobacteroides abscessus (Previously Mycobacterium abscessus) is an emerging microorganism of the newly defined genera Mycobacteroides that causes mainly skin and tissue diseases in humans. The recent availability of total 34 fully sequenced genomes of different strains belonging to this species has provided an opportunity to utilize this genomics data to gain novel insights and guide the development of specific antimicrobial therapies. In the present study, we collected collectively 34 complete genome sequences of M. abscessus from the NCBI GenBank database. Pangenome analysis was conducted on these genomes to understand the genetic diversity and to obtain proteins associated with its core genome. These core proteins were then subjected to various subtractive filters to identify potentia

SUBMITTER: Dar HA 

PROVIDER: S-EPMC8159972 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature