Longitudinal recordings of single units in the basal amygdala during fear conditioning and extinction.

ABSTRACT: The balance between activities of fear neurons and extinction neurons in the basolateral nucleus of the basal amygdala (BA_L) has been hypothesized to encode fear states after extinction. However, it remains unclear whether these neurons are solely responsible for encoding fear states. In this study, we stably recorded single-unit activities in the BA_L during fear conditioning and extinction for 3 days, providing a comprehensive view on how different BA_L neurons respond during fear learning. We found BA_L neurons that showed excitatory responses to the conditioned stimulus (CS) after fear conditioning ('conditioning-potentiated neurons') and another population that showed excitatory responses to the CS after extinction ('extinction-potentiated neur

SUBMITTER: Lee J 

PROVIDER: S-EPMC8159982 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature