A dual-time-window protocol to reduce acquisition time of dynamic tau PET imaging using [¹⁸F]MK-6240.

ABSTRACT:

Background

[¹⁸F]MK-6240 is a PET tracer with sub-nanomolar affinity for neurofibrillary tangles. Therefore, tau quantification is possible with [¹⁸F]MK-6240 PET/CT scans, and it can be used for assessment of Alzheimer's disease. However, long acquisition scans are required to provide fully quantitative estimates of pharmacokinetic parameters. Therefore, on the present study, dual-time-window (DTW) acquisitions was simulated to reduce PET/CT acquisition time, while taking into consideration perfusion changes and possible scanning protocol non-compliance. To that end, time activity curves (TACs) representing a 120-min acquisition (TAC₁₂₀) were simulated using a two-tissue compartment model with metabolite corrected arterial input function from 90-min

SUBMITTER: Kolinger GD 

PROVIDER: S-EPMC8160074 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature