A binge high sucrose diet provokes systemic and cerebral inflammation in rats without inducing obesity.

ABSTRACT: While the dire cardiometabolic consequences of the hypercaloric modern 'Western' diet are well known, there is not much information on the health impact of a high sucrose diet not inducing weight gain. Here, we tested the hypothesis that rats reared with intermittent binge access to sucrose in addition to normal chow would develop an inflammatory response in brain. To test this hypothesis, we undertook serial PET/MRI scans with the TSPO ligand [¹⁸F]DPA714 in a group of (n=9) rats at baseline and again after voluntarily consuming 5% sucrose solution three days a week for three months. Compared to a control group fed with normal chow (n=9), the sucrose rats indeed showed widespread increases in the availability of cerebral binding sites for the microglial marker, despite normal we

SUBMITTER: Patkar OL 

PROVIDER: S-EPMC8160215 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature