The Genomic Architecture and Evolutionary Fates of Supergenes.

ABSTRACT: Supergenes are genomic regions containing sets of tightly linked loci that control multi-trait phenotypic polymorphisms under balancing selection. Recent advances in genomics have uncovered significant variation in both the genomic architecture as well as the mode of origin of supergenes across diverse organismal systems. Although the role of genomic architecture for the origin of supergenes has been much discussed, differences in the genomic architecture also subsequently affect the evolutionary trajectory of supergenes and the rate of degeneration of supergene haplotypes. In this review, we synthesize recent genomic work and historical models of supergene evolution, highlighting how the genomic architecture of supergenes affects their evolutionary fate. We discuss how recent findings on

SUBMITTER: Gutierrez-Valencia J 

PROVIDER: S-EPMC8160319 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature