Replication of Influenza A Virus in Secondary Lymphatic Tissue Contributes to Innate Immune Activation.

ABSTRACT: The replication of viruses in secondary lymphoid organs guarantees sufficient amounts of pattern-recognition receptor ligands and antigens to activate the innate and adaptive immune system. Viruses with broad cell tropism usually replicate in lymphoid organs; however, whether a virus with a narrow tropism relies on replication in the secondary lymphoid organs to activate the immune system remains not well studied. In this study, we used the artificial intravenous route of infection to determine whether Influenza A virus (IAV) replication can occur in secondary lymphatic organs (SLO) and whether such replication correlates with innate immune activation. Indeed, we found that IAV replicates in secondary lymphatic tissue. IAV replication was dependent on the expression of Sialic acid residues

SUBMITTER: Friedrich SK 

PROVIDER: S-EPMC8160763 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature