Evolution of Cancer Vaccines-Challenges, Achievements, and Future Directions.

ABSTRACT: The development of cancer vaccines has been intensively pursued over the past 50 years with modest success. However, recent advancements in the fields of genetics, molecular biology, biochemistry, and immunology have renewed interest in these immunotherapies and allowed the development of promising cancer vaccine candidates. Numerous clinical trials testing the response evoked by tumour antigens, differing in origin and nature, have shed light on the desirable target characteristics capable of inducing strong tumour-specific non-toxic responses with increased potential to bring clinical benefit to patients. Novel delivery methods, ranging from a patient's autologous dendritic cells to liposome nanoparticles, have exponentially increased the abundance and exposure of the antigenic payloads.

SUBMITTER: Tay BQ 

PROVIDER: S-EPMC8160852 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature