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Neuronal Modulators from the Coral-Associated Fungi Aspergillus candidus.

ABSTRACT: Three new p-terphenyl derivatives, named 4″-O-methyl-prenylterphenyllin B (1) and phenylcandilide A and B (17 and 18), and three new indole-diterpene alkaloids, asperindoles E-G (22-24), were isolated together with eighteen known analogues from the fungi Aspergillus candidus associated with the South China Sea gorgonian Junceela fragillis. The structures and absolute configurations of the new compounds were elucidated on the basis of spectroscopic analysis, and DFT/NMR and TDDFT/ECD calculations. In a primary cultured cortical neuronal network, the compounds 6, 9, 14, 17, 18 and 24 modulated spontaneous Ca2+ oscillations and 4-aminopyridine hyperexcited neuronal activity. A preliminary structure-activity relationship was discussed.

SUBMITTER: Peng GY

PROVIDER: S-EPMC8161303 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Neuronal Modulators from the Coral-Associated Fungi Aspergillus candidus.

Peng Gao-Yang GY Kurtán Tibor T Mándi Attila A He Jing J Cao Zheng-Yu ZY Tang Hua H Mao Shui-Chun SC Zhang Wen W

Marine drugs 20210519 5

Three new p-terphenyl derivatives, named 4″-O-methyl-prenylterphenyllin B (1) and phenylcandilide A and B (17 and 18), and three new indole-diterpene alkaloids, asperindoles E-G (22-24), were isolated together with eighteen known analogues from the fungi Aspergillus candidus associated with the South China Sea gorgonian Junceela fragillis. The structures and absolute configurations of the new compounds were elucidated on the basis of ...[more]

PMID: 34069724

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