Disrupted upregulation of salience network connectivity during acute stress in siblings of schizophrenia patients.

ABSTRACT:

Background

An adaptive neural stress response is essential to adequately cope with a changing environment. It was previously argued that sympathetic/noradrenergic activity during acute stress increases salience network (SN) connectivity and reduces executive control network (ECN) connectivity in healthy controls, with opposing effects in the late aftermath of stress. Altered temporal dynamics of these networks in response to stress are thought to play a role in the development of psychopathology in vulnerable individuals.

Methods

We exposed male healthy controls (n = 40, mean age = 33.9) and unaffected siblings of schizophrenia patients (n = 39, mean age = 33.2) to the stress or control condition of the trier social stress test and subsequently investigated resting state fun

SUBMITTER: van Leeuwen JMC 

PROVIDER: S-EPMC8161434 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature