Continuum Crystallization Model Derived from Pharmaceutical Crystallization Mechanisms.

ABSTRACT: The crystallization mechanisms of organic molecules in solution are not well-understood. The mechanistic scenarios where crystalline order evolves directly from the molecularly dissolved state ("classical") and from initially formed amorphous intermediates ("nonclassical") are suggested and debated. Here, we studied crystallization mechanisms of two widely used analgesics, ibuprofen (IbuH) and etoricoxib (ETO), using direct cryogenic transmission electron microscopy (cryo-TEM) imaging. In the IbuH case, parallel crystallization pathways involved diverse phases of high and low density, in which the instantaneous formation of final crystalline order was observed. ETO crystallization started from well-defined round-shaped amorphous intermediates that gradually evolved into crystals. This mech

SUBMITTER: Tsarfati Y 

PROVIDER: S-EPMC8161475 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature