Lateral rectus muscle differentiation potential in paralytic esotropia patients.

ABSTRACT:

Purpose and background

Recently, we found that maximal medial rectus recession and lateral rectus resection in patients with complete lateral rectus paralysis resulted in a partial restoration of abduction. In an attempt to understand some of the mechanisms involved with this effect we examined gene expression profiles of lateral recti from these patients, with our focus being directed to genes related to myogenesis.

Materials and methods

Lateral recti resected from patients with complete lateral rectus paralysis and those from concomitant esotropia (controls) were collected. Differences in gene expression profiles between these two groups were examined using microarray analysis and quantitative Reverse-transcription PCR (qRT-PCR).

Results

A total of 3056 differential

SUBMITTER: Xia Q 

PROVIDER: S-EPMC8161593 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature