Mycobacterium tuberculosis Infection Drives Mitochondria-Biased Dysregulation of Host Transfer RNA-Derived Fragments.

ABSTRACT:

Background

Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis, causes 10 million infections and 1.5 million deaths per year worldwide. The success of Mtb as a human pathogen is directly related to its ability to suppress host responses, which are critical for clearing intracellular pathogens. Emerging evidence suggests that key response pathways may be regulated by a novel class of small noncoding RNA, called transfer RNA (tRNA)-derived fragments (tRFs). tRFs can complex with Argonaute proteins to target and degrade messenger RNA targets, similarly to micro RNAs, but have thus far been overlooked in the context of bacterial infections.

Methods

We generated a novel miRge2.0-based tRF-analysis tool, tRFcluster, and used it to analyze independently generat

SUBMITTER: Looney MM 

PROVIDER: S-EPMC8161643 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature