A variant in TMPRSS2 is associated with decreased disease severity in COVID-19.

ABSTRACT:

Background

Mortality due to COVID-19 caused by SARS-CoV-2 infection varies among populations. Functional relevance of genetic variations in Angiotensin-converting enzyme 2 (ACE2) and Transmembrane serine protease 2 (TMPRSS2), two crucial host factors for viral entry, might explain some of this variation.

Methods

In this comparative study in Indian subjects, we recruited 510 COVID-19 patients and retrieved DNA from 520 controls from a repository. Associations between variants in ACE2 and TMPRSS2 with disease severity were identified by whole exome sequencing (WES, n = 20) and targeted genotyping (n = 1010). Molecular dynamic simulations (MDS) were performed to explore functional relevance of the variants. Cleavage of spike glycoprotei

SUBMITTER: Ravikanth V 

PROVIDER: S-EPMC8161869 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature