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Pathogenesis and characteristics of large ameloblastoma of the jaw: a report of two rare cases.

ABSTRACT: Ameloblastoma is a common odontogenic epithelial tumor that exhibits various biological behaviors, ranging from simple cystic expansion to aggressive solid masses characterized by local invasiveness, a high risk of recurrence, and even malignant transformation. We report on two cases of unusually large solid ameloblastomas. We detected epithelial-mesenchymal transition-related gene expression and HRAS gene single nucleotide polymorphisms, providing possible molecular evidence of mesenchymal morphological changes in ameloblastoma. The detailed analysis of the pathogenesis of these two cases of ameloblastoma may deepen our understanding of this rare disease and offer promising targets for future targeted therapy.

SUBMITTER: Qiao X

PROVIDER: S-EPMC8161878 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Pathogenesis and characteristics of large ameloblastoma of the jaw: a report of two rare cases.

Qiao Xue X Niu Xing X Liu Jiayi J Chen Lijie L Guo Yan Y Zhong Ming M

The Journal of international medical research 20210501 5

Ameloblastoma is a common odontogenic epithelial tumor that exhibits various biological behaviors, ranging from simple cystic expansion to aggressive solid masses characterized by local invasiveness, a high risk of recurrence, and even malignant transformation. We report on two cases of unusually large solid ameloblastomas. We detected epithelial-mesenchymal transition-related gene expression and <i>HRAS</i> gene single nucleotide polymorphisms, providing possible molecular evidence of mesenchym ...[more]

PMID: 34034548

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