Hyperuricemia, urate-lowering therapy, and kidney outcomes: a systematic review and meta-analysis.

ABSTRACT:

Background

Contradictory evidence exists for association of hyperuricemia and kidney function. To investigate the association of hyperuricemia and kidney function decline (hyperuricemia question) and effect of urate-lowering therapies (ULTs) on kidney function (ULT question), we performed a systematic review and meta-analysis.

Methods

MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and CINAHL were searched from inception to July 2020. We selected observational studies for the hyperuricemia question and controlled trials for the ULT question. Two investigators independently assessed study eligibility and abstracted the data. Risk of bias was assessed using the Newcastle-Ottawa Scale and Cochrane risk of bias tool. Meta-analysis was

SUBMITTER: Sharma G 

PROVIDER: S-EPMC8161880 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature