Body mass index and chronic kidney disease outcomes after acute kidney injury: a prospective matched cohort study.

ABSTRACT:

Background

Acute kidney injury (AKI) and obesity are independent risk factors for chronic kidney disease (CKD). This study aimed to determine if obesity modifies risk for CKD outcomes after AKI.

Methods

This prospective multisite cohort study followed adult survivors after hospitalization, with or without AKI. The primary outcome was a combined CKD event of incident CKD, progression of CKD and kidney failure, examined using time-to-event Cox proportional hazards models, adjusted for diabetes status, age, pre-existing CKD, cardiovascular disease status and intensive care unit admission, and stratified by study center. Body mass index (BMI) was added as an interaction term to examine effect modification by body size.

Results

The cohort included 769 participants with AKI

SUBMITTER: MacLaughlin HL 

PROVIDER: S-EPMC8161937 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature