Metformin alters therapeutic effects in the BALB/c tumor therapy model.

ABSTRACT:

Background

Despite considerable medical proceedings, cancer is still a leading cause of death. Major problems for tumor therapy are chemoresistance as well as toxic side effects. In recent years, the additional treatment with the antidiabetic drug metformin during chemotherapy showed promising results in some cases. The aim of this study was to develop an in vitro tumor therapy model in order to further investigate the potential of a combined chemotherapy with metformin.

Methods

Cytotoxic effects of a combined treatment on BALB/c fibroblasts were proven by the resazurin assay. Based on the BALB/c cell transformation assay, the BALB/c tumor therapy model was established successfully with four different and widely used chemotherapeutics from different categories. Namely, Doxor

SUBMITTER: Meyer FB 

PROVIDER: S-EPMC8161985 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature