A cross-cohort analysis of autosomal DNA methylation sex differences in the term placenta.

ABSTRACT:

Background

Human placental DNA methylation (DNAme) data is a valuable resource for studying sex differences during gestation, as DNAme profiles after delivery reflect the cumulative effects of gene expression patterns and exposures across gestation. Here, we present an analysis of sex differences in autosomal DNAme in the uncomplicated term placenta (n = 343) using the Illumina 450K array.

Results

At a false discovery rate < 0.05 and a mean sex difference in DNAme beta value of > 0.10, we identified 162 autosomal CpG sites that were differentially methylated by sex and replicated in an independent cohort of samples (n = 293). Several of these differentially methylated CpG sites were part of larger correlated regions of sex differential DNAme. Although global DNAme levels did

SUBMITTER: Inkster AM 

PROVIDER: S-EPMC8162041 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature