Network abnormalities and interneuron dysfunction in Alzheimer disease.
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ABSTRACT:
SUBMITTER: Palop JJ
PROVIDER: S-EPMC8162106 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Network abnormalities and interneuron dysfunction in Alzheimer disease.
Palop Jorge J JJ Mucke Lennart L
Nature reviews. Neuroscience 20161110 12
The function of neural circuits and networks can be controlled, in part, by modulating the synchrony of their components' activities. Network hypersynchrony and altered oscillatory rhythmic activity may contribute to cognitive abnormalities in Alzheimer disease (AD). In this condition, network activities that support cognition are altered decades before clinical disease onset, and these alterations predict future pathology and brain atrophy. Although the precise causes and pathophysiological con ...[more]
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2021-03-23 | PXD023340 | Pride