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Diversity-oriented synthesis of peptide-boronic acids by a versatile building-block approach.

ABSTRACT: A new strategy for the synthesis of peptide-boronic acids (PBAs) is presented. 20 Fmoc-protected natural amino acids with orthogonal side-chain protection were straightforwardly converted into their corresponding boron analogues in three simple steps. Subsequent immobilisation on commercially available 1-glycerol polystyrene resin and on-resin transformations yielded a diversity of sequences in high purity. The strategy eliminates various synthetic obstacles such as multi-step routes, low yields, and inseparable impurities. The described method comprises great potential to be implemented in automated combinatorial approaches by markedly facilitating the access to a variety of PBAs. The coupling of amino acids or other building blocks with α-aminoboronates allows the creation of hybrid molecules with significant potential in various scientific disciplines, such as medicinal chemistry, structural biology, and materials science.

SUBMITTER: Hinkes SPA

PROVIDER: S-EPMC8162117 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Diversity-oriented synthesis of peptide-boronic acids by a versatile building-block approach.

Hinkes Stefan P A SPA Kämmerer Severin S Klein Christian D P CDP

Chemical science 20200821 36

A new strategy for the synthesis of peptide-boronic acids (PBAs) is presented. 20 Fmoc-protected natural amino acids with orthogonal side-chain protection were straightforwardly converted into their corresponding boron analogues in three simple steps. Subsequent immobilisation on commercially available 1-glycerol polystyrene resin and on-resin transformations yielded a diversity of sequences in high purity. The strategy eliminates various synthetic obstacles such as multi-step routes, low yields ...[more]

PMID: 34094250

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