Dataset Information

Fabrication and Characterization of Poly (vinyl alcohol) and Chitosan Oligosaccharide-Based Blend Films.

ABSTRACT: In the present study, we report the development of poly (vinyl alcohol) (PVA) and chitosan oligosaccharide (COS)-based novel blend films. The concentration of COS was varied between 2.5-10.0 wt% within the films. The inclusion of COS added a brown hue to the films. FTIR spectroscopy revealed that the extent of intermolecular hydrogen bonding was most prominent in the film that contained 5.0 wt% of COS. The diffractograms showed that COS altered the degree of crystallinity of the films in a composition-dependent manner. As evident from the thermal analysis, COS content profoundly impacted the evaporation of water molecules from the composite films. Stress relaxation studies demonstrated that the blend films exhibited more mechanical stability as compared to the control film. The impedance profiles indicated the capacitive-dominant behavior of the prepared films. Ciprofloxacin HCl-loaded films showed excellent antimicrobial activity against Escherichia coli and Bacillus cereus. The prepared films were observed to be biocompatible. Hence, the prepared PVA/COS-based blend films may be explored for drug delivery applications.

SUBMITTER: Qureshi D

PROVIDER: S-EPMC8162339 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Fabrication and Characterization of Poly (vinyl alcohol) and Chitosan Oligosaccharide-Based Blend Films.

Qureshi Dilshad D Sahoo Ayasharani A Mohanty Biswaranjan B Anis Arfat A Kulikouskaya Viktoryia V Hileuskaya Kseniya K Agabekov Vladimir V Sarkar Preetam P Ray Sirsendu Sekhar SS Maji Samarendra S Pal Kunal K

Gels (Basel, Switzerland) 20210506 2

In the present study, we report the development of poly (vinyl alcohol) (PVA) and chitosan oligosaccharide (COS)-based novel blend films. The concentration of COS was varied between 2.5-10.0 wt% within the films. The inclusion of COS added a brown hue to the films. FTIR spectroscopy revealed that the extent of intermolecular hydrogen bonding was most prominent in the film that contained 5.0 wt% of COS. The diffractograms showed that COS altered the degree of crystallinity of the films in a compo ...[more]

PMID: 34066326

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Project description:Nanoparticle-based theranostic agents have emerged as a new paradigm in nanomedicine field for integration of multimodal imaging and therapeutic functions within a single platform. However, the clinical translation of these agents is severely limited by the complexity of fabrication, long-term toxicity of the materials, and unfavorable biodistributions. Here we report an extremely simple and robust approach to develop highly versatile and biocompatible theranostic poly(vinyl alcohol)-porphyrin nanoparticles (PPNs). Through a "one-pot" fabrication process, including the chelation of metal ions and encapsulation of hydrophobic drugs, monodispersenanoparticle could be formed by self-assembly of a very simple and biocompatible building block (poly(vinyl alcohol)-porphyrin conjugate). Using this approach, we could conveniently produce multifunctional PPNs that integrate optical imaging, positron emission tomography (PET), photodynamic therapy (PDT), photothermal therapy (PTT) and drug delivery functions in one formulation. PPNs exhibited unique architecture-dependent fluorescence self-quenching, as well as photodynamic- and photothermal- properties. Near-infrared fluorescence could be amplified upon PPN dissociation, providing feasibility of low-background fluorescence imaging. Doxorubicin (DOX)-loaded PPNs achieved 53 times longer half-life in blood circulation than free DOX. Upon irradiation by near infrared light at a single excitation wavelength, PPNs could be activated to release reactive oxygen species, heat and drugs simultaneously at the tumor sites in mice bearing tumor xenograft, resulting in complete eradication of tumors. Due to their organic compositions, PPNs showed no obvious cytotoxicity in mice via intravenous administration during therapeutic studies. This highly versatile and multifunctional PPN theranostic nanoplatform showed great potential for the integration of multimodal imaging and therapeutic functions towards personalized nanomedicine against cancers.

Dataset Information

Fabrication and Characterization of Poly (vinyl alcohol) and Chitosan Oligosaccharide-Based Blend Films.

Publications

Fabrication and Characterization of Poly (vinyl alcohol) and Chitosan Oligosaccharide-Based Blend Films.

Similar Datasets

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