H/D exchange under mild conditions in arenes and unactivated alkanes with C₆D₆ and D₂O using rigid, electron-rich iridium PCP pincer complexes.

ABSTRACT: The synthesis and characterization of an iridium polyhydride complex (Ir-H4) supported by an electron-rich PCP framework is described. This complex readily loses molecular hydrogen allowing for rapid room temperature hydrogen isotope exchange (HIE) at the hydridic positions and the α-C-H site of the ligand with deuterated solvents such as benzene-d₆, toluene-d₈ and THF-d₈. The removal of 1-2 equivalents of molecular H₂ forms unsaturated iridium carbene trihydride (Ir-H3) or monohydride (Ir-H) compounds that are able to create further unsaturation by reversibly transferring a hydride to the ligand carbene carbon. These species are highly active hydrogen isotope exchange (HIE) catalysts using C₆D₆ or D

SUBMITTER: Smith JD 

PROVIDER: S-EPMC8162389 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature