Lewis acid-assisted Ir(iii) reductive elimination enables construction of seven-membered-ring sulfoxides.

ABSTRACT: Iridium has played an important role in the evolution of C-H activation chemistry over the last half century owing to its high reactivity towards stoichiometric C-H bond cleavage; however, the use of Ir(iii) complexes in catalytic C-H functionalization/C-C bond formation appears to have fallen off significantly. The main problem lies in the reductive elimination step, as iridium has a tendency to form stable and catalytically inactive Ir(iii) species. Herein, with a rationally designed Lewis acid assisted oxidatively induced strategy, the sluggish Ir(iii) reductive elimination is successfully facilitated, enabling the facile C-C bond formation. The X-ray crystal structure of a silver salt adduct of iridacycle and DFT calculations demonstrate that the sulfoxide group acts as a key bridge co

SUBMITTER: Yang W 

PROVIDER: S-EPMC8162422 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature