Challenging the Ostwald rule of stages in mechanochemical cocrystallisation.

ABSTRACT: Mechanochemistry provides an efficient, but still poorly understood route to synthesize and screen for polymorphs of organic solids. We present a hitherto unexplored effect of the milling assembly on the polymorphic outcome of mechanochemical cocrystallisation, tentatively related to the efficiency of mechanical energy transfer to the milled sample. Previous work on mechanochemical cocrystallisation has established that introducing liquid or polymer additives to milling systems can be used to direct polymorphic behavior, leading to extensive studies how the amount and nature of grinding additive affect reaction outcome and polymorphism. Here, focusing on a model pharmaceutical cocrystal of nicotinamide and adipic acid, we demonstrate that changes to the choice of milling media (i.e.

SUBMITTER: Germann LS 

PROVIDER: S-EPMC8162427 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature