A Multicenter Observational Study Evaluating Outcomes Associated With Antibiotic Combination Versus Monotherapy in Patients With Septic Shock.

ABSTRACT:

Objectives

To explore the association between antibiotic combination therapy and in-hospital mortality in patients with septic shock in two tertiary ICUs in different countries.

Design

Retrospective observational study.

Setting

ICUs of two tertiary hospitals, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia, and Rigshospitalet, Copenhagen, Denmark.

Patients

Adult patients with antibiotic treatment greater than or equal to 72 hours and vasopressor therapy greater than or equal to 24 hours.

Intervention

Combination versus mono antibiotic therapy.

Measurements and main results

Combination antibiotic therapy was defined as receiving two or more antibiotics from different classes, started within 12 hours of each other and with an overlappi

SUBMITTER: Torisson G 

PROVIDER: S-EPMC8162507 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature