Leukocyte Activation Profile Assessed by Raman Spectroscopy Helps Diagnosing Infection and Sepsis.

ABSTRACT:

Objectives

Leukocytes are first responders to infection. Their activation state can reveal information about specific host immune response and identify dysregulation in sepsis. This study aims to use the Raman spectroscopic fingerprints of blood-derived leukocytes to differentiate inflammation, infection, and sepsis in hospitalized patients. Diagnostic sensitivity and specificity shall demonstrate the added value of the direct characterization of leukocyte's phenotype.

Design

Prospective nonrandomized, single-center, observational phase-II study (DRKS00006265).

Setting

Jena University Hospital, Germany.

Patients

Sixty-one hospitalized patients (19 with sterile inflammation, 23 with infection without organ dysfunction, 18 with sepsis according to Sepsis-3 defini

SUBMITTER: Ramoji A 

PROVIDER: S-EPMC8162546 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature