Association of SMAD4 loss with drug resistance in clinical cancer patients: A systematic meta-analysis.

ABSTRACT:

Background

Drug resistance frequently led to the failure of chemotherapy for malignant cancers, hence causing cancer relapse. Thus, understanding mechanism of drug resistance in cancer is vital to improve the treatment efficacy. Here, we aim to evaluate the association between SMAD4 expression and the drug resistance in cancers by performing a meta-analysis.

Method

Relevant studies detecting SMAD4 expression in cancer patients treated with chemo-drugs up till December 2020 were systematically searched in four common scientific databases using selected keywords. The pooled hazard ratio (HR) was the ratio of hazard rate between SMAD4neg population vs SMAD4pos population. The HRs and risk ratios (RRs) with 95% confidence intervals (CIs) were used to explore the association betw

SUBMITTER: Xu W 

PROVIDER: S-EPMC8162645 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature