Plasma miRNAs improve the prediction of coronary atherosclerosis in patients with rheumatoid arthritis.

ABSTRACT:

Objective

MicroRNAs (miRNAs) regulate gene expression and are disease biomarkers. Rheumatoid arthritis (RA) patients have accelerated atherosclerosis leading to excess cardiovascular morbidity and mortality, but traditional risk factors for cardiovascular risk stratification are inadequate. In the general population, miRNAs improve cardiovascular risk estimation beyond traditional risk factors. Our objective was to develop a miRNA panel that predicts coronary atherosclerosis in RA patients.

Methods

Plasma small RNA next-generation sequencing (NGS) was performed on 161 RA patients whose Agatston scores for coronary artery calcium were previously measured. Random forest analysis of plasma NGS miRNA expression was used to determine which miRNAs best differentiated between those

SUBMITTER: Ormseth MJ 

PROVIDER: S-EPMC8162679 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature