Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome.

ABSTRACT: Fragile X Syndrome (FXS) is one of the most common monogenic forms of autism and intellectual disability. Preclinical studies in animal models have highlighted the potential of pharmaceutical intervention strategies for alleviating the symptoms of FXS. However, whether treatment strategies can be tailored to developmental time windows that define the emergence of particular phenotypes is unknown. Similarly, whether a brief, early intervention can have long-lasting beneficial effects, even after treatment cessation, is also unknown. To address these questions, we first examined the developmental profile for the acquisition of associative learning in a rat model of FXS. Associative memory was tested using a range of behavioral paradigms that rely on an animal's innate tendency to explore nov

SUBMITTER: Asiminas A 

PROVIDER: S-EPMC8162683 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature