Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis.

ABSTRACT:

Background

Guidelines currently recommend targeting light sedation with dexmedetomidine or propofol for adults receiving mechanical ventilation. Differences exist between these sedatives in arousability, immunity, and inflammation. Whether they affect outcomes differentially in mechanically ventilated adults with sepsis undergoing light sedation is unknown.

Methods

In a multicenter, double-blind trial, we randomly assigned mechanically ventilated adults with sepsis to receive dexmedetomidine (0.2 to 1.5 μg per kilogram of body weight per hour) or propofol (5 to 50 μg per kilogram per minute), with doses adjusted by bedside nurses to achieve target sedation goals set by clinicians according to the Richmond Agitation-Sedation Scale (RASS, on which scores range from -5 [unrespo

SUBMITTER: Hughes CG 

PROVIDER: S-EPMC8162695 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature