Mathematical modeling of multiple pathways in colorectal carcinogenesis using dynamical systems with Kronecker structure.

ABSTRACT: Like many other types of cancer, colorectal cancer (CRC) develops through multiple pathways of carcinogenesis. This is also true for colorectal carcinogenesis in Lynch syndrome (LS), the most common inherited CRC syndrome. However, a comprehensive understanding of the distribution of these pathways of carcinogenesis, which allows for tailored clinical treatment and even prevention, is still lacking. We suggest a linear dynamical system modeling the evolution of different pathways of colorectal carcinogenesis based on the involved driver mutations. The model consists of different components accounting for independent and dependent mutational processes. We define the driver gene mutation graphs and combine them using the Cartesian graph product. This leads to matrix components built by the K

SUBMITTER: Haupt S 

PROVIDER: S-EPMC8162698 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature