Physical activity compared to adiposity and risk of liver-related mortality: Results from two prospective, nationwide cohorts.

ABSTRACT:

Background & aims

Obesity in adulthood has been associated with increased risk of liver-related mortality. Whether higher levels of physical activity counteract the excess risk conferred by obesity remains unknown. We simultaneously evaluated the long-term impact of physical activity and adiposity on liver-related mortality, within 2 nationwide populations.

Methods

We conducted a prospective cohort study of 77,238 women and 48,026 men, with detailed, validated assessments of weekly physical activity (metabolic equivalent task [MET]-hours]), adiposity (body mass index [BMI], waist circumference), and diet, alcohol use and clinical comorbidities, biennially from 1986 through 2012. Using Cox proportional hazards regression models, we calculated multivariable-adjusted hazard rat

SUBMITTER: Simon TG 

PROVIDER: S-EPMC8162838 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature