Evolution of SIVsm in humanized mice towards HIV-2.

ABSTRACT: Through the accumulation of adaptive mutations, HIV-2 originated from SIVsm. To identify these evolutionary changes, a humanized mouse model recapitulated the process that likely enabled this cross-species transmission event. Various adaptive mutations arose, as well as increased virulence and CD4⁺ T-cell decline as the virus was passaged in humanized mice.

SUBMITTER: Curlin J 

PROVIDER: S-EPMC8162839 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature