Rh(iii)-catalyzed tandem annulative redox-neutral arylation/amidation of aromatic tethered alkenes.

ABSTRACT: Transition-metal-catalyzed directed C-H functionalization has emerged as a powerful and straightforward tool to construct C-C bonds and C-N bonds. Among these processes, the intramolecular annulative alkene hydroarylation reaction has received much attention because this intramolecular annulation can produce more complex and high value-added structural motifs found in numerous natural products and bioactive molecules. Despite remarkable progress, these annulative protocols developed to date remain limited to hydroarylation and functionalization of one side of alkenes, thus largely limiting the structural diversity and complexity. Herein, we developed a rhodium(iii)-catalyzed tandem annulative arylation/amidation reaction of aromatic tethered alkenes to deliver a variety of 2,3-dihydro-3-be

SUBMITTER: Chen C 

PROVIDER: S-EPMC8162841 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature