Structure-guided discovery of a luminescent theranostic toolkit for living cancer cells and the imaging behavior effect.

ABSTRACT: Dual-functional theranostics are powerful tools that can allow for the in-field understanding of cancer pathology, yet their use is held back by the paucity of suitable theranostics for living systems. Moreover, typical in vitro screening conditions for probe molecules do not necessarily generate candidates that can function effectively in the natural in cellulo environment, limiting their follow-up use in living systems. We introduce herein a general strategy for the development of an iridium(iii) theranostic by grafting a well-known inhibitor as a "binding unit" onto an iridium(iii) complex precursor as a "signaling unit". To further optimize their emissive properties, we explored the effect of imaging behavior by incorporating different substituents onto the parental "sign

SUBMITTER: Wu C 

PROVIDER: S-EPMC8162881 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature